Molecular determinants for a cardiovascular collapse in anthrax

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Molecular determinants for a cardiovascular collapse in anthrax.

Bacillus anthracis releases two bipartite proteins, lethal toxin and edema factor, that contribute significantly to the progression of anthrax-associated shock. As blocking the anthrax toxins prevents disease, the toxins are considered the main virulence factors of the bacterium. The anthrax bacterium and the anthrax toxins trigger multi-organ failure associated with enhanced vascular permeabil...

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ژورنال

عنوان ژورنال: Frontiers in Bioscience

سال: 2014

ISSN: 1945-0494,1945-0508

DOI: 10.2741/e697